Laboratoire Différenciation et Communication Neuroendocrine, Endocrine et Germinale
INSERM U1239

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PROFIL

Luca GRUMOLATO

ÉQUIPE : Plasticité et Physiopathologie Neuroendocrine

E-MAIL : luca.grumolato@univ-rouen.fr

STATUT : Maître de conférences des universités

ORCID : 0000-0001-8231-3032

After a Master’s degree in Molecular Biology from the University of Torino (Italy), Luca Grumolato obtained a Ph.D. in Cell Biology at the University of Rouen. He then moved to New York for his postdoctoral studies in Stu Aaronson’s lab, where he worked on the role of Wnt signaling in cancer.

In 2011, Luca was awarded a Chair of Excellence from Inserm and the University of Rouen and he joined the DC2N (now NorDiC) laboratory. Since 2022, Luca is co-director of the PPN team. His group is interested in cancer targeted therapies and, more specifically, in how intratumor heterogeneity drives drug resistance.

DERNIÈRES PUBLICATIONS DE LUCA GRUMOLATO

Mechanisms of Acquired Resistance and Tolerance to EGFR Targeted Therapy in Non-Small Cell Lung Cancer

Publié en 2023 dans Cancers (Basel)

Équipe : Plasticité et Physiopathologie Neuroendocrine

MET exon 14 skipping mutation is a hepatocyte growth factor (HGF)-dependent oncogenic driver in vitro and in humanised HGF knock-in mice

Publié en 2023 dans Molecular Oncology

Équipe : Plasticité et Physiopathologie Neuroendocrine

High endogenous CCL2 expression promotes the aggressive phenotype of human inflammatory breast cancer

Publié en 2021 dans Nature Communications

Équipe : Plasticité et Physiopathologie Neuroendocrine

ROR2 has a protective role in melanoma by inhibiting Akt activity, cell-cycle progression, and proliferation

Publié en 2021 dans Journal of Biomedical Science

Équipe : Plasticité et Physiopathologie Neuroendocrine

Tolerant/Persister cancer cells and the path to resistance to targeted therapy

Publié en 2020 dans Cells

Équipe : Plasticité et Physiopathologie Neuroendocrine

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